10 Best cough cold and flu medicine for adults of 2025

Save up to 27% off

Best Choice

1

Vicks

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps
9.6

Exceptional

Our Rating
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Value for Money

2

Coricidin HBP
Coricidin HBP Maximum Strength Cold & Flu Day & Night Sugar-Free Liquid Twinpack, Decongestant-Free Cold Medicine for Adults with High Blood Pressure -12 Fl Oz (Pack of 2)
Main highlights

Decongestant-Free Maximum Strength Relief
Coricidin HBP provides fast, decongestant-free relief for cold & flu symptoms without raising blood pressure.

Ideal for High Blood Pressure Patients
Perfect for adults with high blood pressure needing cold & flu relief.

Highly Effective Nighttime Cough Suppressant
Customers praise its nighttime formula as the best for stopping coughs and aiding sleep.
Key specs
- symptom relief:Cold & flu symptoms
- target age:Adults
- form:Liquid
- active ingredient:Acetaminophen
- dosage:12 fl ounce
9.5

Excellent

Our Rating

9.7
quality of sleep

9.3
pain management

8.0
Flavor
3

Tylenol
Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count

27% Off
Main highlights

Comprehensive Cold Flu Relief
24-count pack offers multi-symptom relief for cold and flu.

Day Night Usage
Ideal for day and night relief with separate formulas.

Highly Praised Value
Customers appreciate the value and effectiveness of the product.
Key specs
- features:Cold & flu relief
- product dimensions:4.52 x 0.78 x 2.95 inches
- active ingredients:Acetaminophen, Phenylephrine HCl
- decongestant:Phenylephrine HCl
- saline solution:N/A
9.4

Excellent

Our Rating
4

Coricidin HBP
Coricidin HBP Maximum Strength Multi-Symptom Flu Tablets For Body Aches, Body Pains Cold and Cough Relief: Flu Medicine for Adults with High Blood Pressure - 24 Count
Main highlights

Decongestant-Free Symptom Relief
Provides flu relief without elevating blood pressure, ideal for adults with hypertension.

Ideal for Seasonal Flu
Perfect for managing seasonal flu symptoms, including body aches and cough.

Praised for Blood Pressure Safety
Customers appreciate its safety for high blood pressure sufferers.
Key specs
- symptom relief:Fever, cough, aches
- target age:Adults
- form:Tablet
- active ingredient:Acetaminophen
- dosage:N/A
9.3

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Tussin Severe CF Max Syrup, Multi-Symptom Cough, Cold and Flu Liquid Medicine, Non-Drowsy, Relieves Cough, Sore Throat, Body Aches, Fever, Nasal and Chest Congestion, 8 fl oz
Main highlights

Maximum Strength Relief
Provides maximum strength relief for cough, congestion, and fever.

Ideal for Multi-Symptom Relief
Perfect for cold and flu symptoms like cough and sore throat.

Praised for Cost-Effectiveness
Customers appreciate its affordability compared to similar products.
9.2

Excellent

Our Rating

8.9
worth the money

8.0
Flavor
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6

Vicks
VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz
Main highlights

Specially Formulated for High Blood Pressure
Decongestant-free cold and flu relief suitable for those with high blood pressure.

Ideal for Day and Night Use
Provides effective symptom relief both during the day and at night.

Effective Multi-Symptom Relief
Praised for easing fever, aches, cough, and providing restful sleep.
Key specs
- symptom relief:Headache, fever, sore throat
- target age:N/A
- form:N/A
- active ingredient:N/A
- dosage:One dose
9.1

Excellent

Our Rating

9.9
simple to consume

9.3
pain management

9.3
Flavor
7

Tylenol
Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine with Acetaminophen Pain Reliever & Fever Reducer, Nasal Decongestant & Antihistamine, Value Pack, 2 ct. of 8 fl. oz

16% Off
Main highlights

Dual Formula for Comprehensive Relief
Combines non-drowsy daytime and soothing nighttime formulas for 24-hour cold and flu symptom relief.

Ideal for Cold and Flu Season
Perfect for managing symptoms like fever, cough, and congestion during the flu season.

Customer Praised Flavor
Flavors are appreciated by users, making it easier to consume.
9.0

Excellent

Our Rating

9.9
pain management

9.7
worth the money

9.5
Flavor
8

ALKA-SELTZER PLUS
Alka-Seltzer Plus Power Max Cold & Flu Day+Night Medicine: Cough Suppressant, Cold and Flu Medicine For Adults and Children 12 Years and Older, 36 Count, Packaging May Vary
Main highlights

Comprehensive Cold and Flu Relief
Provides relief from headache, fever, cough, nasal/sinus congestion for adults and children 12+.

Day and Night Use
Ideal for continuous relief with distinct daytime and nighttime formulas.

Praised Smaller Size
Customers appreciate the smaller pill size compared to older versions.
Key specs
- symptom relief:Cold & flu symptoms
- target age:12 years and older
- form:N/A
- active ingredient:N/A
- dosage:N/A
8.9

Very Good

Our Rating

8.4
simple to consume

8.0
worth the money
9

Amazon Basic Care
Amazon Basic Care Nighttime Cold and Flu Medicine, Maximum Strength, Original Flavor Liquid, Multi-Symptom Relief, 12 fl oz (Pack of 1)
Main highlights

Key Features and Benefits
Maximum strength formula with acetaminophen, dextromethorphan, and doxylamine for multi-symptom relief, offering up to 6 hours of nighttime relief.

Ideal Use Cases
Perfect for adults and children over 12 suffering from cold and flu symptoms like fever, sore throat, sneezing, runny nose, and cough.

Customer Reviews Highlight
Most praised for its effective relief that promotes better sleep, with users appreciating the liquid form and original flavor.
Key specs
- symptom relief:cold and flu
- target age:12 and older
- form:liquid
- active ingredient:acetaminophen, dextromethorphan, doxylamine
- dosage:N/A
8.6

Very Good

Our Rating

8.9
worth the money

8.7
Flavor
10

Vicks
Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ
Main highlights

Key Features
Maximum strength relief for cold & flu symptoms, both day and night, with fast-acting results to take you from 9 to none.

Ideal Use Cases
Perfect for those needing non-drowsy relief during the day and restful relief at night for severe cold and flu symptoms.

Customer Praise
Most reviews highlight Vicks` longstanding trust and effectiveness, emphasizing how quickly and reliably it alleviates the worst cold and flu symptoms.
8.5

Good

Our Rating

9.3
Comfort

9.1
worth the money

8.7
Flavor

10 Best cough cold and flu medicine for adults of 2025

1

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps

2

Coricidin HBP Maximum Strength Cold & Flu Day & Night Sugar-Free Liquid Twinpack, Decongestant-Free Cold Medicine for Adults with High Blood Pressure -12 Fl Oz (Pack of 2)

9.7

9.3

8.0

3

Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count

4

Coricidin HBP Maximum Strength Multi-Symptom Flu Tablets For Body Aches, Body Pains Cold and Cough Relief: Flu Medicine for Adults with High Blood Pressure - 24 Count

5

Amazon Basic Care Tussin Severe CF Max Syrup, Multi-Symptom Cough, Cold and Flu Liquid Medicine, Non-Drowsy, Relieves Cough, Sore Throat, Body Aches, Fever, Nasal and Chest Congestion, 8 fl oz

8.9

8.0

6

VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz

9.9

9.3

9.3

7

Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine with Acetaminophen Pain Reliever & Fever Reducer, Nasal Decongestant & Antihistamine, Value Pack, 2 ct. of 8 fl. oz

9.9

9.7

9.5

8

Alka-Seltzer Plus Power Max Cold & Flu Day+Night Medicine: Cough Suppressant, Cold and Flu Medicine For Adults and Children 12 Years and Older, 36 Count, Packaging May Vary

8.4

8.0

9

Amazon Basic Care Nighttime Cold and Flu Medicine, Maximum Strength, Original Flavor Liquid, Multi-Symptom Relief, 12 fl oz (Pack of 1)

8.9

8.7

10

Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ

9.3

9.1

8.7

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